《Frontiers in Microbiology》大肠杆菌C321.△A的转录组和蛋白质组的比较分析
将非典型氨基酸(ncAAs)引入到蛋白质中已被证明是调控蛋白质结构和功能以及研究许多生物学过程的有效手段。提高…
Nat.Commun. | 嵌合体翻译系统的定向进化,可用于高效的整合非天然氨基酸以及营养缺陷型菌体的构建
2021年12月,浙江大学林世贤团队在Nature Communications发表题为“Directed-e…
ACS Catal. | 机器学习引导的酶定向进化文库设计:训练集组成对序列空间探索的影响
2021年11月,东京大学Koji Tsuda团队和日本东北大学Mitsuo Umetsu团队共同在ACS C…
利用分隔式自我复制(CSR)改造来自于Thermus thermophilus的I型DNA聚合酶
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Nat. Commun. | 用于遗传密码扩展的吡咯赖氨酰-tRNA合成酶/tRNA对和经典合成酶/tRNA对的嵌合设计
文章链接:https://www.nature.com/articles/s41467-020-16898-y…
ACS Catalysis:具备多底物特异性和对映立体选择性的新型麻黄碱脱氢酶的鉴定及研究
DOI: 10.1021/acscatal.9b00621 Tarek Shanati,Cameron Loc…
Design and use of de novo cascades for new benzylisoquinoline biosynthesis
摘要: 苄基异喹啉生物碱是一类具有化学结构多样性的化合物,存在于开花植物的次级代谢产物中。目前已知的苄基异喹啉…
Protonation state, binding affinity and conformational change, what can free energy computation tell us
嘉宾:邬知易博士,牛津大学 主持人:于浩然 时间:2019年8月20日晚8点 摘要: 随着计算成本的不断降低与…
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