The RCSB Protein Data Bank (rcsb.org) contains information about the 3D shapes of proteins, nucleic acids, and complex assemblies. This resource is powered by the structural data from the Protein Data Bank Archive. As a member of the Worldwide PDB, the RCSB PDB curates the PDB data and integrates them with related scientific resources to provide a structural view of biology and medicine for research and education. PDB-101 (pdb101.rcsb.org) is an online portal for teachers, students, and the general public to promote exploration in the world of proteins and nucleic acids. Learning about the diverse shapes and functions of these biological macromolecules helps to understand all aspects of biomedicine and agriculture, from protein synthesis to health and disease to biological energy.