王初课题组


网站: https://mp.weixin.qq.com/s/ZlQW1C0WCmjIR_ENixLlvQ

Our research programs focus on the development and application of multi-disciplinary tools in chemoproteomics, biochemistry, bioinformatics and computational structure biology to 1) globally uncover novel funtional sites in enzymes that are post-translationally regulated by endogenous reactive metabolites or targeted by drug compounds; 2) interrogate the underlying molecular mechanisms by which these modifications regulate protein function to perturb key cellular signaling pathways and 3) develop computational tools to predict, model and design such protein-small molecule interactions. These studies have the great potential to provide penetrating mechanistic insights into the molecular basis for numerous diseases functionally linked to metabolic disorder as well as to integrate and streamline efforts in inhibitor discovery, drug design and the functional annotation of uncharacterized enzymes in the post-genomic era.


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号外 | 王初课题组与陈鹏课题组合作开发通用活体蛋白激活技术

近日,本课题组与北京大学化学与分子工程学院陈鹏课题组合作,在Nature杂志上发表题为“Time-resolv…

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