2017年4月12日天津大学元英进教授实验室，在期刊《Energy & Environmental Science》上发表人工发电菌群文章。该期刊为能源领域顶尖期刊，影响因子高达25.427。这是元英进课题组继人工合成酵母染色体后，在合成多细胞体系领域取得重大突破。有关合成酵母染色体的研究，可以查看链接重磅|天津大学连发两篇《Science》文章报道合成生物学重大进展。
在本次发表的研究中，他们按照“劳动分工”设计原则，合成了一个重组大肠杆菌、枯草芽胞杆菌与希瓦氏菌三菌体系用于产电。在这一菌群中，大肠杆菌消化葡萄糖产乳酸作为碳源与电子供体；枯草芽胞杆菌产核黄素作为电子载体；希瓦氏菌作为产电菌发电时，将乳酸氧化为乙酸，反哺给大肠杆菌和芽胞杆菌作为碳源。
于是，这三种菌形成一个互养群体，以“在一起更好”方式产电。0.28克葡萄糖以近55.7%的高能量转化效率持续发电15天以上。菌群组成与电能输出在整个操作周期中保持稳定。并且，人工体系在初始接种比例改变的情况下表现出了高度的功能鲁棒性。
这一系统是对于“劳动分工”的探索以及对体系的设计、优化的策略，能够为未来理性设计更加复杂、高效、能够应用于生物能源、环境修复等领域的人工合成混菌体系提供一个新视角。
文章标题A three-species microbial consortium for power generation
文章链接http://pubs.rsc.org/en/content/articlelanding/2017/ee/c6ee03705d#!divAbstract
转发自http://pudong.cibt.ac.cn/index.aspx?menuid=9&type=articleinfo&lanmuid=128&infoid=827&language=cn
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