摘要:
苄基异喹啉生物碱是一类具有化学结构多样性的化合物,存在于开花植物的次级代谢产物中。目前已知的苄基异喹啉生物碱多达25000种,并且它们大多数都具有药理学活性。例如吗啡是一种强效的镇痛剂,黄连素具有消炎的作用,诺丝卡宾是常用的抗癌药物等。我们通常从植物中提取苄基异喹啉,但是提取难度大且纯度低,化学全合成的方法又经常受到产物手性的限制。所以我们以合成生物学方法作为指导,用生物催化的途径合成苄基异喹啉生物碱。
参考文献:Wang, Yu, et al. “Design and Use of de novo Cascades for the Biosynthesis of New Benzylisoquinoline Alkaloids.” Angewandte Chemie 131.30 (2019): 10226-10231.
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